This paper presents an overview of the ECSEL 1 project entitled “MegaModelling at runtime – Scalable model-based framework for continuous development and runtime validation of complex systems” (MegaM@Rt2), whose aim is to address the challenges facing MDE. Driven by both large and small industrial enterprises, with the support of research partners and technology providers, MegaM@Rt2 aims to deliver a framework of tools and methods for: 1) system engineering/design and continuous development, 2) related runtime analysis and 3) global models and traceability management. Diverse industrial use cases (covering strategic domains such as aeronautics, railway, construction and telecommunications) will integrate and demonstrate the validity of the MegaM@Rt2 solution