The main objective of the ANASTACIA project is to address cyber-security concerns by researching, developing and demonstrating a holistic solution enabling trust and security by-design for Cyber Physical Systems (CPS) based on IoT and Cloud architectures. ANASTACIA develops a trustworthy-by-design security framework which will address all the phases of the ICT Systems Development Lifecycle (SDL) and will be able to take autonomous decisions through the use of new networking technologies such as Software Defined Networking (SDN) and Network Function Virtualisation (NFV) and intelligent and dynamic security enforcement and monitoring methodologies and tools.